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Ge, J., Normant, E., Porter, J.R., Ali, J.A., Dembski, M.S., Gao, Y., Georges, A.T., Grenier, L., Pak, R.H., Patterson, J., Sydor, J.R., Tibbitts, T.T., Tong, J.K., Adams, J. and Palombella, V.J. Design, Synthesis, and Biological Evaluation of Hydroquinone Derivatives of 17-Amino-17-demethoxygeldanamycin as Potent, Water-Soluble Inhibitors of Hsp90. J. Med. Chem. 2006, 49, 4606-4615.

Sydor, J.R., Normant, E., Pien, C.S., Porter, J.R., Ge, J., Grenier, L., Pak, R.H., Ali, J.A., Dembski, M.S., Hudak, J., Patterson, J., Penders, C., Pink, M., Read, M.A., Sang, J., Woodward, C., Zhang, Y., Grayzel, D.S., Wright, J., Barrett, J.A., Palombella, V.J., Adams, J. and Tong, J.K. Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90. PNAS 2006;103;17408-17413.

Tillotson, B., Mann, D., Brophy, E., Ali, J., Palombella, V. and Fritz, C. A Novel Binding Assay for Native Bcl-2 on Intact Mitochondria. American Association for Cancer Research Annual Meeting, 3628, 2007.

Wylie, A., Hafeez, N., Conley, J., White, K., Mann, D., Palombella, V., and Fritz, C. (2007) A Unique Apoptosis Marker Profile for Antagonists of Bcl-2. American Association for Cancer Research Annual Meeting, 5163, 2007.

Van den Abbeele, A. D., Yap, J. T., Grayzel, D. S., Walker, J., Demetri, G.D. Inhibition and flare patterns of metabolic response to the Heat Shock Protein 90 (Hsp90) inhibitor IPI-504 visualized by FDG-PET in patients with advanced gastrointestinal stromal tumors (GIST) resistant to tyrosine kinase inhibitor (TKI) therapy. American Society of Clinical Oncology Annual Meeting, 2007.

Peng, C., Brain, J., Hu, Y., Goodrich, A., Kong, L., Grayzel, D., Pak, R., Read, M. and Li, S. Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I–induced leukemia and suppresses leukemic stem cells. Blood, 15 July 2007,Volume 110, Number 2.

Demetri, G.D., George, S., Morgan, J., Wagner, A., Quigley, M.T., Polson, K., Pokela, J., van den Abbeele, A., Chugh, R., Walker, J., Adams, J. and Grayzel, D. (2007) Inhibition of the heat shock protein 90 (Hsp90) chaperone with the novel agent IPI-504 to overcome resistance to tyrosine kinase inhibitors (TKIs) in metastatic gist: Updated results of a phase I trial. American Society of Clinical Oncology Annual Meeting, 2007.

Sequist, L., Janne, P., Sweeney, J., Walker, J., Grayzel, D., Lynch, T. (2007) Phase 1/2 Trial of the Novel Hsp90 Inhibitor, IPI-504, in Patients with Relapsed and/or Refractory Stage IIIb or Stage IV Non-Small Cell Lung Cancer (NSCLC) Stratified by EGFR Mutation Status. ACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, B79, 2007.

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